Structure‐Activity Relationship Studies of Hydantoin‐Cored Ligands for Smoothened Receptor

Structure‐Activity Relationship Studies of Hydantoin‐Cored Ligands for Smoothened Receptor

Abstract An underside binding site was recently identified in the transmembrane domain of smoothened receptor (SMO). Herein, we report efforts in the exploration of new insights into the interactions between the ligand and SMO. The hydantoin core in the middle of the parent compound was found to be...

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Bibliographic Details
Main Authors: Dr. Yang Liu, Dr. Fang Zhou, Kang Ding, Dr. Dongxiang Xue, Zhihao Zhu, Cuixia Li, Fei Li, Dr. Yueming Xu, Prof. Fei Xu, Prof. Zhiping Le, Prof. Suwen Zhao, Prof. Houchao Tao
Format: Article
Language:English
Published: Wiley-VCH 2021-10-01
Series:ChemistryOpen
Subjects:
anti-cancer
halogen bonding
molecular dynamics
smoothened receptor
structural biology
Online Access:https://doi.org/10.1002/open.202100216

Internet

https://doi.org/10.1002/open.202100216

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