Protective effects of the mTOR inhibitor everolimus on cytoskeletal injury in human podocytes are mediated by RhoA signaling.

Protective effects of the mTOR inhibitor everolimus on cytoskeletal injury in human podocytes are mediated by RhoA signaling.

Podocytes are highly differentiated kidney cells playing an important role in maintaining the glomerular filtration barrier. Particularly, the integrity of the actin cytoskeleton is crucial as cytoskeletal damage associated with foot process effacement and loss of slit diaphragms constitutes a major...

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Bibliographic Details
Main Authors: Stefanie Jeruschke, Anja Katrin Büscher, Jun Oh, Moin Ahson Saleem, Peter Friedrich Hoyer, Stefanie Weber, Perihan Nalbant
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3572151?pdf=render

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http://europepmc.org/articles/PMC3572151?pdf=render

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