Microglial infiltration mediates cognitive dysfunction in rat models of hypothalamic obesity via a hypothalamic-hippocampal circuit involving the lateral hypothalamic area

Microglial infiltration mediates cognitive dysfunction in rat models of hypothalamic obesity via a hypothalamic-hippocampal circuit involving the lateral hypothalamic area

This study aimed to explore the mechanism underlying cognitive dysfunction mediated by the lateral hypothalamic area (LHA) in a hypothalamic-hippocampal circuit in rats with lesion-induced hypothalamic obesity (HO). The HO model was established by electrically lesioning the hypothalamic nuclei. The...

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Bibliographic Details
Main Authors: Chong Song, Wei Wei, Tong Wang, Min Zhou, Yunshi Li, Bing Xiao, Dongyi Huang, Junwei Gu, Linyong Shi, Junjie Peng, Dianshi Jin
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
hypothalamic obesity
memory dysfunction
lateral hypothalamic area
microglial cells
neural circuits
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2022.971100/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2022.971100/full

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