Novel MRI deformation-heterogeneity radiomic features are associated with molecular subgroups and overall survival in pediatric medulloblastoma: Preliminary findings from a multi-institutional study

Novel MRI deformation-heterogeneity radiomic features are associated with molecular subgroups and overall survival in pediatric medulloblastoma: Preliminary findings from a multi-institutional study

IntroductionMedulloblastoma (MB) is a malignant, heterogenous brain tumor. Advances in molecular profiling have led to identifying four molecular subgroups of MB (WNT, SHH, Group 3, Group 4), each with distinct clinical behaviors. We hypothesize that (1) aggressive MB tumors, growing heterogeneously...

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Bibliographic Details
Main Authors: Sukanya Iyer, Marwa Ismail, Benita Tamrazi, Ralph Salloum, Peter de Blank, Ashley Margol, Ramon Correa, Jonathan Chen, Kaustav Bera, Volodymyr Statsevych, Mai-Lan Ho, Pranjal Vaidya, Ruchika Verma, Debra Hawes, Alexander Judkins, Pingfu Fu, Anant Madabhushi, Pallavi Tiwari
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Oncology
Subjects:
medulloblastoma
deformation
molecular subgroups
survival
LASSO
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.915143/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.915143/full

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