PDGF-BB accelerates TSCC via fibroblast lactates limiting miR-26a-5p and boosting mitophagy

PDGF-BB accelerates TSCC via fibroblast lactates limiting miR-26a-5p and boosting mitophagy

Abstract The tumor microenvironment and cancer-associated fibroblasts (CAFs) play crucial roles in tumor development, and their metabolic coupling remains unclear. Clinical data showed a positive correlation between PDGF-BB, CAFs, and glycolysis in the tumor microenvironment of oral tongue squamous...

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Bibliographic Details
Main Authors: Jianguo Xu, Li Bian, Dingyun You, Ziliang Li, Tingting Wang, Yiting Li, Xiaobin Ren, Yongwen He
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Cancer Cell International
Subjects:
PDGF-BB
Lactate
Mitophagy
Cancer-associated fibroblasts
Metabolism reprogramming
Online Access:https://doi.org/10.1186/s12935-023-03172-6

Internet

https://doi.org/10.1186/s12935-023-03172-6

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