Simple IHC reveals complex MMR alternations than PCR assays: Validation by LCM and next‐generation sequencing

Simple IHC reveals complex MMR alternations than PCR assays: Validation by LCM and next‐generation sequencing

Abstract Evaluation of the status of mismatch repair (MMR) in tumors is crucial for determining the application of immune checkpoint inhibitors (ICIs). Conventional PCR (MSI‐PCR) is the gold standard for confirming the MMR status. However, it requires visual confirmation and presents difficulties in...

Full description

Bibliographic Details
Main Authors: Kenji Amemiya, Yosuke Hirotsu, Yuki Nagakubo, Shunsuke Watanabe, Saki Amemiya, Hitoshi Mochizuki, Toshio Oyama, Tetsuo Kondo, Masao Omata
Format: Article
Language:English
Published: Wiley 2022-12-01
Series:Cancer Medicine
Subjects:
heterogeneity
immunohistochemistry
MMR
MSI
next‐generation sequencing
Online Access:https://doi.org/10.1002/cam4.4832

Internet

https://doi.org/10.1002/cam4.4832

Similar Items