Iterative Usage of Fixed and Random Effect Models for Powerful and Efficient Genome-Wide Association Studies.

Iterative Usage of Fixed and Random Effect Models for Powerful and Efficient Genome-Wide Association Studies.

False positives in a Genome-Wide Association Study (GWAS) can be effectively controlled by a fixed effect and random effect Mixed Linear Model (MLM) that incorporates population structure and kinship among individuals to adjust association tests on markers; however, the adjustment also compromises t...

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Bibliographic Details
Main Authors: Xiaolei Liu, Meng Huang, Bin Fan, Edward S Buckler, Zhiwu Zhang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-02-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4734661?pdf=render

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http://europepmc.org/articles/PMC4734661?pdf=render

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