Turnover number predictions for kinetically uncharacterized enzymes using machine and deep learning
Abstract The turnover number k cat, a measure of enzyme efficiency, is central to understanding cellular physiology and resource allocation. As experimental k cat estimates are unavailable for the vast majority of enzymatic reactions, the development of accurate computational prediction methods is h...
Main Authors: | Alexander Kroll, Yvan Rousset, Xiao-Pan Hu, Nina A. Liebrand, Martin J. Lercher |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-07-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-023-39840-4 |
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