Large, Nested Variant of Urothelial Carcinoma Is Enriched with Activating Mutations in Fibroblast Growth Factor Receptor-3 among Other Targetable Mutations

Large, Nested Variant of Urothelial Carcinoma Is Enriched with Activating Mutations in Fibroblast Growth Factor Receptor-3 among Other Targetable Mutations

The large, nested variant of urothelial carcinoma (LNVUC) is characterized by bland histomorphology mimicking that of benign von Brunn nests. In the current study, we aimed to investigate the <i>Fibroblast Growth Factor Receptor-3 (FGFR-3</i>) activation and missense mutation in 38 cases...

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Bibliographic Details
Main Authors: Yaser Gamallat, Mitra Afsharpad, Soufiane El Hallani, Christopher A. Maher, Nimira Alimohamed, Eric Hyndman, Tarek A. Bismar
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Cancers
Subjects:
large nested variant of urothelial carcinoma (LNVUC)
<i>fibroblast growth factor receptor-3</i> (<i>FGFR-3</i>)
metastatic urothelial carcinoma
whole-exome sequencing
targeted sequencing
Online Access:https://www.mdpi.com/2072-6694/15/12/3167

Internet

https://www.mdpi.com/2072-6694/15/12/3167

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