Netrin-1 mediates nerve innervation and angiogenesis leading to discogenic pain

Netrin-1 mediates nerve innervation and angiogenesis leading to discogenic pain

Objective: Discogenic low back pain (LBP) is associated with nociceptive nerve fibers that grow into degenerated intervertebral discs (IVD) but the etiopathogenesis of disease is not fully understood. The purpose of this study was to clarify the role of Netrin-1 in causing discogenic LBP. Methods: T...

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Bibliographic Details
Main Authors: Bingjie Zheng, Shengwen Li, Yufeng Xiang, Wentian Zong, Qingliang Ma, Shiyu Wang, Haihao Wu, Haixin Song, Hong Ren, Jian Chen, Junhui Liu, Fengdong Zhao
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Journal of Orthopaedic Translation
Subjects:
Netrin-1
Discogenic back pain
Nerve innervation
Intervertebral disc degeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X22001334

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http://www.sciencedirect.com/science/article/pii/S2214031X22001334

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