Sensory deficit screen identifies nsf mutation that differentially affects SNARE recycling and quality control

Summary: The AAA+ NSF complex is responsible for SNARE complex disassembly both before and after membrane fusion. Loss of NSF function results in pronounced developmental and degenerative defects. In a genetic screen for sensory deficits in zebrafish, we identified a mutation in nsf, I209N, that imp...

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Bibliographic Details
Main Authors: Yan Gao, Yousuf A. Khan, Weike Mo, K. Ian White, Matthew Perkins, Richard A. Pfuetzner, Josef G. Trapani, Axel T. Brunger, Teresa Nicolson
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Cell Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472300356X