SCAP deficiency facilitates obesity and insulin resistance through shifting adipose tissue macrophage polarization

SCAP deficiency facilitates obesity and insulin resistance through shifting adipose tissue macrophage polarization

Introduction: Sterol regulatory element binding protein (SREBP) cleavage-associating protein (SCAP) is a sterol-regulated escort protein that translocates SREBPs from the endoplasmic reticulum to the Golgi apparatus, thereby activating lipid metabolism and cholesterol synthesis. Although SCAP regula...

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Bibliographic Details
Main Authors: Jae-Ho Lee, Sun Hee Lee, Eun-Ho Lee, Jeong-Yong Cho, Dae-Kyu Song, Young Jae Lee, Taeg Kyu Kwon, Byung-Chul Oh, Kae Won Cho, Timothy F. Osborne, Tae-Il Jeon, Seung-Soon Im
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Journal of Advanced Research
Subjects:
SCAP
White adipose tissue
Macrophages
Cholesterol 25-hydroxylase
Cholesterol efflux
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123222001242

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http://www.sciencedirect.com/science/article/pii/S2090123222001242

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