Personalized statin treatment plan using counterfactual approach with multi-objective optimization over benefits and risks

Personalized statin treatment plan using counterfactual approach with multi-objective optimization over benefits and risks

Background: Statins are a class of drugs that lower cholesterol levels in the blood by inhibiting an enzyme called 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase. High cholesterol levels can lead to plaque buildup in the arteries, which can cause Atherosclerotic Cardiovascular Disease(AS...

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Bibliographic Details
Main Authors: Yue Liang, Pui Ying Yew, Matt Loth, Terrence J. Adam, Julian Wolfson, Peter J. Tonellato, Chin-Lin Chi
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Informatics in Medicine Unlocked
Subjects:
Statin
Statin-associated-symptoms
Counterfactual prediction
Generalized propensity score
Generalized overlap weights
Clinical trial simulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2352914823002083

Internet

http://www.sciencedirect.com/science/article/pii/S2352914823002083

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