The extrachromosomal circular DNA atlas of aged and young mouse brains
Abstract Extrachromosomal circular DNA (eccDNA) refers to a distinct class of circular DNA molecules that exist independently from linear chromosomal DNA. Extensive evidence has firmly established the significant involvement of eccDNA in cancer initiation, progression, and evolutionary processes. Ho...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-03-01
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| Series: | Scientific Data |
| Online Access: | https://doi.org/10.1038/s41597-024-03146-x |
| _version_ | 1827301428623835136 |
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| author | Xiaoning Hong Jing Li Peng Han Shaofu Li Jiaying Yu Haoran Zhang Jiang Li Yonghui Dang Xi Xiang |
| author_facet | Xiaoning Hong Jing Li Peng Han Shaofu Li Jiaying Yu Haoran Zhang Jiang Li Yonghui Dang Xi Xiang |
| author_sort | Xiaoning Hong |
| collection | DOAJ |
| description | Abstract Extrachromosomal circular DNA (eccDNA) refers to a distinct class of circular DNA molecules that exist independently from linear chromosomal DNA. Extensive evidence has firmly established the significant involvement of eccDNA in cancer initiation, progression, and evolutionary processes. However, the relationship between eccDNA and brain aging remains elusive. Here, we employed extrachromosomal circular DNA sequencing (Circle-seq) to generate a comprehensive dataset of eccDNA from six brain structures of both young and naturally-aged mice, including the olfactory bulb, medial prefrontal cortex, nucleus accumbens, caudate putamen, hippocampus, and cerebellum. Furthermore, through database annotation, we characterized the properties of mouse brain eccDNA, thereby gaining insights into the potential functions of eccDNA in the mouse brain. In conclusion, our study addresses a previously unexplored area by providing a comprehensive molecular characterization of eccDNA in brain tissues. The data presented in the study can be used as a fundamental resource to associate the molecular phenotypes of eccDNA with brain aging and gain deep insights into the biological role of eccDNA in mammalian brain aging. |
| first_indexed | 2024-04-24T16:22:58Z |
| format | Article |
| id | doaj.art-fa494b2ddb8c45b891dcb4a73436b2b4 |
| institution | Directory Open Access Journal |
| issn | 2052-4463 |
| language | English |
| last_indexed | 2024-04-24T16:22:58Z |
| publishDate | 2024-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Data |
| spelling | doaj.art-fa494b2ddb8c45b891dcb4a73436b2b42024-03-31T11:10:16ZengNature PortfolioScientific Data2052-44632024-03-011111810.1038/s41597-024-03146-xThe extrachromosomal circular DNA atlas of aged and young mouse brainsXiaoning Hong0Jing Li1Peng Han2Shaofu Li3Jiaying Yu4Haoran Zhang5Jiang Li6Yonghui Dang7Xi Xiang8Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-Sen UniversityCollege of Medicine and Forensics, Xi’an Jiaotong University Health Science CenterDepartment of Biology, University of CopenhagenCollege of Medicine and Forensics, Xi’an Jiaotong University Health Science CenterScientific Research Center, The Seventh Affiliated Hospital of Sun Yat-Sen UniversityCollege of Medicine and Forensics, Xi’an Jiaotong University Health Science CenterScientific Research Center, The Seventh Affiliated Hospital of Sun Yat-Sen UniversityCollege of Medicine and Forensics, Xi’an Jiaotong University Health Science CenterScientific Research Center, The Seventh Affiliated Hospital of Sun Yat-Sen UniversityAbstract Extrachromosomal circular DNA (eccDNA) refers to a distinct class of circular DNA molecules that exist independently from linear chromosomal DNA. Extensive evidence has firmly established the significant involvement of eccDNA in cancer initiation, progression, and evolutionary processes. However, the relationship between eccDNA and brain aging remains elusive. Here, we employed extrachromosomal circular DNA sequencing (Circle-seq) to generate a comprehensive dataset of eccDNA from six brain structures of both young and naturally-aged mice, including the olfactory bulb, medial prefrontal cortex, nucleus accumbens, caudate putamen, hippocampus, and cerebellum. Furthermore, through database annotation, we characterized the properties of mouse brain eccDNA, thereby gaining insights into the potential functions of eccDNA in the mouse brain. In conclusion, our study addresses a previously unexplored area by providing a comprehensive molecular characterization of eccDNA in brain tissues. The data presented in the study can be used as a fundamental resource to associate the molecular phenotypes of eccDNA with brain aging and gain deep insights into the biological role of eccDNA in mammalian brain aging.https://doi.org/10.1038/s41597-024-03146-x |
| spellingShingle | Xiaoning Hong Jing Li Peng Han Shaofu Li Jiaying Yu Haoran Zhang Jiang Li Yonghui Dang Xi Xiang The extrachromosomal circular DNA atlas of aged and young mouse brains Scientific Data |
| title | The extrachromosomal circular DNA atlas of aged and young mouse brains |
| title_full | The extrachromosomal circular DNA atlas of aged and young mouse brains |
| title_fullStr | The extrachromosomal circular DNA atlas of aged and young mouse brains |
| title_full_unstemmed | The extrachromosomal circular DNA atlas of aged and young mouse brains |
| title_short | The extrachromosomal circular DNA atlas of aged and young mouse brains |
| title_sort | extrachromosomal circular dna atlas of aged and young mouse brains |
| url | https://doi.org/10.1038/s41597-024-03146-x |
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