Quantification of Fosfomycin in Combination with Nine Antibiotics in Human Plasma and Cation-Adjusted Mueller-Hinton II Broth via LCMS

Quantification of Fosfomycin in Combination with Nine Antibiotics in Human Plasma and Cation-Adjusted Mueller-Hinton II Broth via LCMS

Fosfomycin-based combination therapy has emerged as an attractive option in our armamentarium due to its synergistic activity against carbapenem-resistant Gram-negative bacteria (CRGNB). The ability to simultaneously measure fosfomycin and other antibiotic drug levels will support in vitro and clini...

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Bibliographic Details
Main Authors: Kelvin Kau-Kiat Goh, Wilson Ghim-Hon Toh, Daryl Kim-Hor Hee, Edwin Zhi-Wei Ting, Nathalie Grace Sy Chua, Farah Iffah Binte Zulkifli, Li-Jiao Sin, Thuan-Tong Tan, Andrea Lay-Hoon Kwa, Tze-Peng Lim
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Antibiotics
Subjects:
fosfomycin
LCMS/MS
antibiotics
plasma
TDM
validation
Online Access:https://www.mdpi.com/2079-6382/11/1/54

Internet

https://www.mdpi.com/2079-6382/11/1/54

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