The inhibition of IRE1alpha/XBP1 axis prevents EBV-driven lymphomagenesis in NSG mice

The inhibition of IRE1alpha/XBP1 axis prevents EBV-driven lymphomagenesis in NSG mice

ABSTRACT Post-transplant lymphoproliferative disorders (PTLD) are a group of heterogeneous diseases originating in conditions of immune deficiency, whose main driver is considered to be Epstein-Barr virus (EBV). Here, we explored the role of IRE1alpha/XBP1s axis in EBV-driven lymphomagenesis in an N...

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Bibliographic Details
Main Authors: Andrea Arena, Maria Anele Romeo, Agnese Po, Rossella Benedetti, Maria Saveria Gilardini Montani, Roberta Gonnella, Roberta Santarelli, Aurelia Gaeta, Enrico De Smaele, Mara Cirone
Format: Article
Language:English
Published: American Society for Microbiology 2023-12-01
Series:Microbiology Spectrum
Subjects:
EBV
lymphomagenesis
IRE1alpha/XBP1s
NSG mice
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02636-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.02636-23

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