Novel therapeutic approach to slow down the inflammatory cascade in acute/subacute spinal cord injury: Early immune therapy with lipopolysaccharide enhanced neuroprotective effect of combinational therapy of granulocyte colony-stimulating factor and bone-marrow mesenchymal stem cell in spinal cord injury

Novel therapeutic approach to slow down the inflammatory cascade in acute/subacute spinal cord injury: Early immune therapy with lipopolysaccharide enhanced neuroprotective effect of combinational therapy of granulocyte colony-stimulating factor and bone-marrow mesenchymal stem cell in spinal cord injury

Bone-marrow mesenchymal stem cells (BM-MSCs) have not yet proven any significant therapeutic efficacy in spinal cord injury (SCI) clinical trials, due to the hostile microenvironment of the injured spinal cord at the acute phase. This study aims to modulate the inflammatory milieu by lipopolysacchar...

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Bibliographic Details
Main Authors: Shiva Hashemizadeh, Saereh Hosseindoost, Ameneh Omidi, Hossein Aminianfar, Somayeh Ebrahimi-Barough, Jafar Ai, Babak Arjmand, Mahmoudreza Hadjighassem
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
combination therapy
inflammation
bone-marrow mesenchymal stem cell
G-CSF
LPS
spinal cord injury
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2022.993019/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2022.993019/full

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