BMP and TGFbeta pathways in human central chondrosarcoma: enhanced endoglin and Smad 1 signaling in high grade tumors

BMP and TGFbeta pathways in human central chondrosarcoma: enhanced endoglin and Smad 1 signaling in high grade tumors

<p>Abstract</p> <p>Background</p> <p>As major regulators of normal chondrogenesis, the bone morphogenic protein (BMP) and transforming growth factor β (TGFB) signaling pathways may be involved in the development and progression of central chondrosarcoma. In order to unc...

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Bibliographic Details
Main Authors: Boeuf Stephane, Bovée Judith VMG, Lehner Burkhard, van den Akker Brendy, van Ruler Maayke, Cleton-Jansen Anne-Marie, Richter Wiltrud
Format: Article
Language:English
Published: BMC 2012-10-01
Series:BMC Cancer
Subjects:
Conventional central chondrosarcoma
Bone tumor
Chondrogenic differentiation
Bone morphogenic proteins
Transforming growth factor β
Online Access:http://www.biomedcentral.com/1471-2407/12/488

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http://www.biomedcentral.com/1471-2407/12/488

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