Characterization and use of the ECV304 autoantigenic citrullinome to understand anti-citrullinated protein/peptide autoantibodies in rheumatoid arthritis

Characterization and use of the ECV304 autoantigenic citrullinome to understand anti-citrullinated protein/peptide autoantibodies in rheumatoid arthritis

Abstract Background Anti-citrullinated protein antibodies (ACPAs) are highly specific for rheumatoid arthritis (RA). In vivo, ACPAs target peptidyl-citrulline epitopes (cit-) in a variety of proteins (cit-prot-ACPAs) and derived peptides (cit-pept-ACPAs) generated via the peptidylarginine deiminase...

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Bibliographic Details
Main Authors: Natalia Regine de França, Henri André Ménard, Maximilien Lora, Zhijie Zhou, Joyce Rauch, Carol Hitchon, Luís Eduardo Coelho Andrade, Inés Colmegna
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Arthritis Research & Therapy
Subjects:
ECV304
Autocitrullinome
Peptidylarginine deiminases
ACPAs
Rheumatoid arthritis
Online Access:https://doi.org/10.1186/s13075-021-02698-2

Internet

https://doi.org/10.1186/s13075-021-02698-2

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