Fat matters: Fermented whole milk potentiates the anti-colitis effect of Propionibacterium freudenreichii
Inflammatory bowel diseases (IBD) constitute a growing concern in western countries. They coincide with gut microbiota dysbiosis, including a loss of immunomodulatory bacteria. Accordingly, probiotic products containing selected immunomodulatory bacterial strains mitigate IBD. Selected strains of Pr...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-07-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464623002141 |
| _version_ | 1797801811132809216 |
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| author | Marine Mantel Tales Fernando da Silva Rafael Gloria Danièle Vassaux Kátia Duarte Vital Valbert Nascimento Cardoso Simone Odília Antunes Fernandes Éric Guédon Yves Le Loir Ana Maria Caetano Faria Malvyne Rolli-Derkinderen Vasco Azevedo Gwénaël Jan |
| author_facet | Marine Mantel Tales Fernando da Silva Rafael Gloria Danièle Vassaux Kátia Duarte Vital Valbert Nascimento Cardoso Simone Odília Antunes Fernandes Éric Guédon Yves Le Loir Ana Maria Caetano Faria Malvyne Rolli-Derkinderen Vasco Azevedo Gwénaël Jan |
| author_sort | Marine Mantel |
| collection | DOAJ |
| description | Inflammatory bowel diseases (IBD) constitute a growing concern in western countries. They coincide with gut microbiota dysbiosis, including a loss of immunomodulatory bacteria. Accordingly, probiotic products containing selected immunomodulatory bacterial strains mitigate IBD. Selected strains of Propionibacterium freudenreichii display promising modulatory properties and prevent colitis in animal models. Dairy matrices protect propionibacteria immunomodulatory surface antigens during digestive transit. However, the functional role of the dairy matrix components in such fermented dairy products remains unknown. In the present workthis study, P. freudenreichii CIRM-BIA129, a probiotic strain known for its anti-inflammatory properties, was used to ferment whole milk, skim milk or skim milk ultrafiltrate. The preventive potential of fermented products was tested in DSS-induced mice colitis, in comparison with their unfermented counterparts. P. freudenreichii-fermented milk prevented colitis. Dairy fat in the fermented product potentiated the anti-colitis effects of the probiotic. This work opens new perspectives for developing immunomodulatory functional fermented foods. |
| first_indexed | 2024-03-13T04:56:09Z |
| format | Article |
| id | doaj.art-fa50fe64345641d9b55744735b1baa52 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-03-13T04:56:09Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-fa50fe64345641d9b55744735b1baa522023-06-18T05:01:25ZengElsevierJournal of Functional Foods1756-46462023-07-01106105614Fat matters: Fermented whole milk potentiates the anti-colitis effect of Propionibacterium freudenreichiiMarine Mantel0Tales Fernando da Silva1Rafael Gloria2Danièle Vassaux3Kátia Duarte Vital4Valbert Nascimento Cardoso5Simone Odília Antunes Fernandes6Éric Guédon7Yves Le Loir8Ana Maria Caetano Faria9Malvyne Rolli-Derkinderen10Vasco Azevedo11Gwénaël Jan12INRAE, UMR 1253, STLO, L’institut Agro, Rennes, France; Nantes Université, Inserm, TENS, The Enteric Nervous System in Gut and Brain Diseases, IMAD, Nantes, FranceINRAE, UMR 1253, STLO, L’institut Agro, Rennes, France; Institute of Biological Sciences, Department of Genetics, Ecology, and Evolution, Universidade Federal de Minas Gerais, Belo Horizonte, BrazilInstitute of Biological Sciences, Department of Genetics, Ecology, and Evolution, Universidade Federal de Minas Gerais, Belo Horizonte, BrazilINRAE, UMR 1253, STLO, L’institut Agro, Rennes, FrancePharmacy School, Universidade Federal de Minas Gerais, Belo Horizonte, BrazilPharmacy School, Universidade Federal de Minas Gerais, Belo Horizonte, BrazilPharmacy School, Universidade Federal de Minas Gerais, Belo Horizonte, BrazilINRAE, UMR 1253, STLO, L’institut Agro, Rennes, FranceINRAE, UMR 1253, STLO, L’institut Agro, Rennes, FranceInstitute of Biological Sciences, Department of Genetics, Ecology, and Evolution, Universidade Federal de Minas Gerais, Belo Horizonte, BrazilNantes Université, Inserm, TENS, The Enteric Nervous System in Gut and Brain Diseases, IMAD, Nantes, FranceInstitute of Biological Sciences, Department of Genetics, Ecology, and Evolution, Universidade Federal de Minas Gerais, Belo Horizonte, BrazilINRAE, UMR 1253, STLO, L’institut Agro, Rennes, France; Corresponding author at: INRAE STLO, 65 rue de Saint Brieuc, 35042 Rennes Cedex, France.Inflammatory bowel diseases (IBD) constitute a growing concern in western countries. They coincide with gut microbiota dysbiosis, including a loss of immunomodulatory bacteria. Accordingly, probiotic products containing selected immunomodulatory bacterial strains mitigate IBD. Selected strains of Propionibacterium freudenreichii display promising modulatory properties and prevent colitis in animal models. Dairy matrices protect propionibacteria immunomodulatory surface antigens during digestive transit. However, the functional role of the dairy matrix components in such fermented dairy products remains unknown. In the present workthis study, P. freudenreichii CIRM-BIA129, a probiotic strain known for its anti-inflammatory properties, was used to ferment whole milk, skim milk or skim milk ultrafiltrate. The preventive potential of fermented products was tested in DSS-induced mice colitis, in comparison with their unfermented counterparts. P. freudenreichii-fermented milk prevented colitis. Dairy fat in the fermented product potentiated the anti-colitis effects of the probiotic. This work opens new perspectives for developing immunomodulatory functional fermented foods.http://www.sciencedirect.com/science/article/pii/S1756464623002141ProbioticCheeseInflammationColitisImmunomodulationDairy fat |
| spellingShingle | Marine Mantel Tales Fernando da Silva Rafael Gloria Danièle Vassaux Kátia Duarte Vital Valbert Nascimento Cardoso Simone Odília Antunes Fernandes Éric Guédon Yves Le Loir Ana Maria Caetano Faria Malvyne Rolli-Derkinderen Vasco Azevedo Gwénaël Jan Fat matters: Fermented whole milk potentiates the anti-colitis effect of Propionibacterium freudenreichii Journal of Functional Foods Probiotic Cheese Inflammation Colitis Immunomodulation Dairy fat |
| title | Fat matters: Fermented whole milk potentiates the anti-colitis effect of Propionibacterium freudenreichii |
| title_full | Fat matters: Fermented whole milk potentiates the anti-colitis effect of Propionibacterium freudenreichii |
| title_fullStr | Fat matters: Fermented whole milk potentiates the anti-colitis effect of Propionibacterium freudenreichii |
| title_full_unstemmed | Fat matters: Fermented whole milk potentiates the anti-colitis effect of Propionibacterium freudenreichii |
| title_short | Fat matters: Fermented whole milk potentiates the anti-colitis effect of Propionibacterium freudenreichii |
| title_sort | fat matters fermented whole milk potentiates the anti colitis effect of propionibacterium freudenreichii |
| topic | Probiotic Cheese Inflammation Colitis Immunomodulation Dairy fat |
| url | http://www.sciencedirect.com/science/article/pii/S1756464623002141 |
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