Mechanism of action of non-camptothecin inhibitor Genz-644282 in topoisomerase I inhibition

Mechanism of action of non-camptothecin inhibitor Genz-644282 in topoisomerase I inhibition

Non-camptothecin topoisomerase I inhibitor, Genz, shows potent activity against camptothecin-resistant cells through double-strand break induced cytotoxicity.

Bibliographic Details
Main Authors: Masahiro Nishida, Takeshi Terabayashi, Shigeru Matsuoka, Tomoko Okuma, Sawako Adachi, Tadashi Tomo, Masanori Kawano, Kazuhiro Tanaka, Hiroshi Tsumura, Hirofumi Anai, Toshimasa Ishizaki, Yoshihiro Nishida, Katsuhiro Hanada
Format: Article
Language:English
Published: Nature Portfolio 2022-09-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-022-03920-w

Internet

https://doi.org/10.1038/s42003-022-03920-w

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