Stage-Dependent Increase of Systemic Immune Activation and CCR5<sup>+</sup>CD4<sup>+</sup> T Cells in Filarial Driven Lymphedema in Ghana and Tanzania

Stage-Dependent Increase of Systemic Immune Activation and CCR5<sup>+</sup>CD4<sup>+</sup> T Cells in Filarial Driven Lymphedema in Ghana and Tanzania

Chronic lymphedema caused by infection of <i>Wuchereria bancrofti</i> is a disfiguring disease that leads to physical disability, stigmatization, and reduced quality of life. The edematous changes occur mainly on the lower extremities and can progress over time due to secondary bacterial...

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Bibliographic Details
Main Authors: Abu Abudu Rahamani, Sacha Horn, Manuel Ritter, Anja Feichtner, Jubin Osei-Mensah, Vera Serwaa Opoku, Linda Batsa Debrah, Thomas F. Marandu, Antelmo Haule, Jacklina Mhidze, Abdallah Ngenya, Max Demetrius, Ute Klarmann-Schulz, Michael Hoelscher, Christof Geldmacher, Achim Hoerauf, Akili Kalinga, Alexander Y. Debrah, Inge Kroidl
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Pathogens
Subjects:
CD4<sup>+</sup> T cell activation
lymphatic filariasis
lymphedema
CCR5
PD-1
HLADR/CD38
Online Access:https://www.mdpi.com/2076-0817/12/6/809

Internet

https://www.mdpi.com/2076-0817/12/6/809

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