Metformin alleviates cholestasis-associated nephropathy through regulating oxidative stress and mitochondrial function

Metformin alleviates cholestasis-associated nephropathy through regulating oxidative stress and mitochondrial function

Background and aim: Cholestasis-associated renal injury or cholemic nephropathy (CN) is a serious clinical problem. Previous studies mentioned that oxidative stress and mitochondrial impairment play a role in CN. There is no specific pharmacological intervention for CN. Metformin is an anti-diabetic...

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Bibliographic Details
Main Authors: Mohammad Mehdi Ommati, Hamidreza Mohammadi, Khadijeh Mousavi, Negar Azarpira, Omid Farshad, Reyhaneh Dehghani, Asma Najibi, Sedigheh Kamran, Hossein Niknahad, Reza Heidari
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2021-09-01
Series:Liver Research
Subjects:
Metformin
Bile acids
Cholestasis
Cirrhosis
Oxidative stress
Mitochondrial function
Online Access:http://www.sciencedirect.com/science/article/pii/S2542568420300726

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http://www.sciencedirect.com/science/article/pii/S2542568420300726

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