Effects of replication domains on genome-wide UV-induced DNA damage and repair.

Nucleotide excision repair is the primary repair mechanism that removes UV-induced DNA lesions in placentals. Unrepaired UV-induced lesions could result in mutations during DNA replication. Although the mutagenesis of pyrimidine dimers is reasonably well understood, the direct effects of replication...

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Bibliographic Details
Main Authors: Yanchao Huang, Cem Azgari, Mengdie Yin, Yi-Ying Chiou, Laura A Lindsey-Boltz, Aziz Sancar, Jinchuan Hu, Ogun Adebali
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-09-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1010426