METTL23 mutation alters histone H3R17 methylation in normal-tension glaucoma

METTL23 mutation alters histone H3R17 methylation in normal-tension glaucoma

Normal-tension glaucoma (NTG) is a heterogeneous disease characterized by retinal ganglion cell (RGC) death leading to cupping of the optic nerve head and visual field loss at normal intraocular pressure (IOP). The pathogenesis of NTG remains unclear. Here, we describe a single nucleotide mutation i...

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Bibliographic Details
Main Authors: Yang Pan, Akiko Suga, Itaru Kimura, Chojiro Kimura, Yuriko Minegishi, Mao Nakayama, Kazutoshi Yoshitake, Daisuke Iejima, Naoko Minematsu, Megumi Yamamoto, Fumihiko Mabuchi, Mitsuko Takamoto, Yukihiro Shiga, Makoto Araie, Kenji Kashiwagi, Makoto Aihara, Toru Nakazawa, Takeshi Iwata
Format: Article
Language:English
Published: American Society for Clinical Investigation 2022-11-01
Series:The Journal of Clinical Investigation
Subjects:
Ophthalmology
Online Access:https://doi.org/10.1172/JCI153589

Internet

https://doi.org/10.1172/JCI153589

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