Use of a small molecule integrin activator as a systemically administered vaccine adjuvant in controlling Chagas disease

Use of a small molecule integrin activator as a systemically administered vaccine adjuvant in controlling Chagas disease

Abstract The development of suitable safe adjuvants to enhance appropriate antigen-driven immune responses remains a challenge. Here we describe the adjuvant properties of a small molecule activator of the integrins αLβ2 and α4β1, named 7HP349, which can be safely delivered systemically independent...

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Bibliographic Details
Main Authors: Nandadeva Lokugamage, Imran H. Chowdhury, Ronald J. Biediger, Robert V. Market, Sayadeth Khounlo, Navin D. Warier, Shen-An Hwang, Jeffrey K. Actor, Darren G. Woodside, Upendra Marathi, Peter Vanderslice, Nisha Jain Garg
Format: Article
Language:English
Published: Nature Portfolio 2021-09-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-021-00378-5

Internet

https://doi.org/10.1038/s41541-021-00378-5

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