Use of a small molecule integrin activator as a systemically administered vaccine adjuvant in controlling Chagas disease
Abstract The development of suitable safe adjuvants to enhance appropriate antigen-driven immune responses remains a challenge. Here we describe the adjuvant properties of a small molecule activator of the integrins αLβ2 and α4β1, named 7HP349, which can be safely delivered systemically independent...
Main Authors: | Nandadeva Lokugamage, Imran H. Chowdhury, Ronald J. Biediger, Robert V. Market, Sayadeth Khounlo, Navin D. Warier, Shen-An Hwang, Jeffrey K. Actor, Darren G. Woodside, Upendra Marathi, Peter Vanderslice, Nisha Jain Garg |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2021-09-01
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Series: | npj Vaccines |
Online Access: | https://doi.org/10.1038/s41541-021-00378-5 |
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