Genetic variations that influence paclitaxel pharmacokinetics and intracellular effects that may contribute to chemotherapy-induced neuropathy: A narrative review

Genetic variations that influence paclitaxel pharmacokinetics and intracellular effects that may contribute to chemotherapy-induced neuropathy: A narrative review

Taxanes, particularly paclitaxel and docetaxel, are chemotherapeutic agents commonly used to treat breast cancers. A frequent side effect is chemotherapy-induced peripheral neuropathy (CIPN) that occurs in up to 70% of all treated patients and impacts the quality of life during and after treatment....

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Bibliographic Details
Main Authors: Ken B. Johnson, Anukriti Sharma, N. Lynn Henry, Mei Wei, Bihua Bie, Courtney E. Hershberger, Emily E. Rhoades, Alper Sen, Ryan E. Johnson, Jacob Steenblik, Jennifer Hockings, G. Thomas Budd, Charis Eng, Joseph Foss, Daniel M. Rotroff
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Pain Research
Subjects:
paclitaxel
pharmacokinetics
chemotherapy-induced neuropathy
genetic
epigenetic
Online Access:https://www.frontiersin.org/articles/10.3389/fpain.2023.1139883/full

Internet

https://www.frontiersin.org/articles/10.3389/fpain.2023.1139883/full

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