Gene-corrected p.A30P SNCA patient-derived isogenic neurons rescue neuronal branching and function

Gene-corrected p.A30P SNCA patient-derived isogenic neurons rescue neuronal branching and function

Abstract Parkinson’s disease (PD) is characterised by the degeneration of A9 dopaminergic neurons and the pathological accumulation of alpha-synuclein. The p.A30P SNCA mutation generates the pathogenic form of the alpha-synuclein protein causing an autosomal-dominant form of PD. There are limited st...

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Bibliographic Details
Main Authors: Peter A. Barbuti, Jochen Ohnmacht, Bruno F. R. Santos, Paul M. Antony, François Massart, Gérald Cruciani, Claire M. Dording, Lukas Pavelka, Nicolas Casadei, Yong-Jun Kwon, Rejko Krüger
Format: Article
Language:English
Published: Nature Portfolio 2021-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-01505-x

Internet

https://doi.org/10.1038/s41598-021-01505-x

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