Endoplasmic Reticulum Stress Contributes to Gefitinib-Induced Apoptosis in Glioma

Endoplasmic Reticulum Stress Contributes to Gefitinib-Induced Apoptosis in Glioma

Adequate stress on the Endoplasmic Reticulum (ER) with the Unfolded Protein Response (UPR) could maintain glioma malignancy. Uncontrolled ER stress, on the other hand, predisposes an apoptosis-dominant UPR program. We studied here the proapoptotic actions of the Epidermal Growth Factor Receptor (EGF...

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Bibliographic Details
Main Authors: Cheng-Yi Chang, Ping-Ho Pan, Chih-Cheng Wu, Su-Lan Liao, Wen-Ying Chen, Yu-Hsiang Kuan, Wen-Yi Wang, Chun-Jung Chen
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
apoptosis
EGFR inhibitors
ER stress
glioma
Noxa
Online Access:https://www.mdpi.com/1422-0067/22/8/3934

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https://www.mdpi.com/1422-0067/22/8/3934

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