Diaryl Urea Derivative Molecule Inhibits Cariogenic Streptococcus mutans by Affecting Exopolysaccharide Synthesis, Stress Response, and Nitrogen Metabolism

Diaryl Urea Derivative Molecule Inhibits Cariogenic Streptococcus mutans by Affecting Exopolysaccharide Synthesis, Stress Response, and Nitrogen Metabolism

Different small molecules have been developed to target cariogenic bacteria Streptococcus mutans. Based on target-based designing and in silico screening, a novel diaryl urea derivative, 1,3-bis[3,5-bis(trifluoromethyl)phenyl]urea (BPU), has previously been found effective in inhibiting the growth o...

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Bibliographic Details
Main Authors: Ying Liao, Mengyun Zhang, Xingnan Lin, Fuhua Yan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
dental caries
Streptococcus mutans
transcriptomic study
small molecules
stress response
nitrogen metabolism
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.904488/full

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https://www.frontiersin.org/articles/10.3389/fcimb.2022.904488/full

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