Inhibitory mechanism of peptides with a repeating hydrophobic and hydrophilic residue pattern on interleukin-10

Inhibitory mechanism of peptides with a repeating hydrophobic and hydrophilic residue pattern on interleukin-10

Interleukin 10 (IL-10) is a cytokine that is able to downregulate inflammation. Its overexpression is directly associated with the difficulty in the clearance of chronic viral infections, such as chronic hepatitis B, hepatitis C and HIV infection, and infection-related cancer. IL-10 signaling blocka...

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Bibliographic Details
Main Authors: Guoying Ni, Yuejian Wang, Scott Cummins, Shelley Walton, Kate Mounsey, Xiaosong Liu, Ming Q. Wei, Tianfang Wang
Format: Article
Language:English
Published: Taylor & Francis Group 2017-03-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
circular dichroism spectroscopy
elisa
interleukin-10 inhibiting peptide
interleukin-10 receptor
molecular dynamic simulation
surface plasmon resonance spectroscopy
Online Access:http://dx.doi.org/10.1080/21645515.2016.1238537

Internet

http://dx.doi.org/10.1080/21645515.2016.1238537

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