Sex-dependent alterations in social behaviour and cortical synaptic activity coincide at different ages in a model of Alzheimer's disease.

Besides memory deficits, Alzheimer's disease (AD) patients suffer from neuropsychiatric symptoms, including alterations in social interactions, which are subject of a growing number of investigations in transgenic models of AD. Yet the biological mechanisms underlying these behavioural alterati...

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Bibliographic Details
Main Authors: Cyril Bories, Matthieu J Guitton, Carl Julien, Cyntia Tremblay, Milène Vandal, Meriem Msaid, Yves De Koninck, Frédéric Calon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3454358?pdf=render