NF-κB RelB suppresses the inflammatory gene expression programs of dendritic cells by competing with RelA for binding to target gene promoters

NF-κB RelB suppresses the inflammatory gene expression programs of dendritic cells by competing with RelA for binding to target gene promoters

Abstract A group of autoinflammatory disorders termed relopathies arise as a consequence of NF-κB dysregulation. Genetic loss of the NF-κB subunit RelB in humans and mice leads to autoimmunity and lethal multi-organ inflammatory pathology. Our recent study showed that this inflammatory pathology is...

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Bibliographic Details
Main Authors: Héctor I. Navarro, Allison E. Daly, Benancio Rodriguez, Sunny Wu, Kim A. Ngo, Anna Fraser, Allison Schiffman, Yi Liu, Stephen T. Smale, Jennifer J. Chia, Alexander Hoffmann
Format: Article
Language:English
Published: Nature Publishing Group 2025-02-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-024-00767-9

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https://doi.org/10.1038/s41421-024-00767-9

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