High-resolution mapping of the neutralizing and binding specificities of polyclonal sera post-HIV Env trimer vaccination

High-resolution mapping of the neutralizing and binding specificities of polyclonal sera post-HIV Env trimer vaccination

Mapping polyclonal serum responses is critical to rational vaccine design. However, most high-resolution mapping approaches involve isolating and characterizing individual antibodies, which incompletely defines the polyclonal response. Here we use two complementary approaches to directly map the spe...

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Bibliographic Details
Main Authors: Adam S Dingens, Payal Pratap, Keara Malone, Sarah K Hilton, Thomas Ketas, Christopher A Cottrell, Julie Overbaugh, John P Moore, PJ Klasse, Andrew B Ward, Jesse D Bloom
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-01-01
Series:eLife
Subjects:
HIV
polyclonal sera
Env trimer immunization
mutational antigenic profiling
electron microscopy polyclonal epitope mapping
Online Access:https://elifesciences.org/articles/64281

Internet

https://elifesciences.org/articles/64281

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