Self-Organization of Stem Cell Colonies and of Early Mammalian Embryos: Recent Experiments Shed New Light on the Role of Autonomy vs. External Instructions in Basic Body Plan Development

Self-Organization of Stem Cell Colonies and of Early Mammalian Embryos: Recent Experiments Shed New Light on the Role of Autonomy vs. External Instructions in Basic Body Plan Development

“Organoids”, i.e., complex structures that can develop when pluripotent or multipotent stem cells are maintained in three-dimensional cultures, have become a new area of interest in stem cell research. Hopes have grown that when focussing experimentally on the mechanisms behind this type of in vitro...

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Bibliographic Details
Main Author: Hans-Werner Denker
Format: Article
Language:English
Published: MDPI AG 2016-10-01
Series:Cells
Subjects:
development
morphogenesis
stem cells
pattern formation
organoids
gastrulation
primitive streak
axis formation
basic body plan
implantation
in vitro models
ethics
Online Access:http://www.mdpi.com/2073-4409/5/4/39

Internet

http://www.mdpi.com/2073-4409/5/4/39

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