Sub-Convulsing Dose Administration of Pilocarpine Reduces Glycemia, Increases Anxiety-Like Behavior and Decelerates Cortical Spreading Depression in Rats Suckled on Various Litter Sizes

Sub-Convulsing Dose Administration of Pilocarpine Reduces Glycemia, Increases Anxiety-Like Behavior and Decelerates Cortical Spreading Depression in Rats Suckled on Various Litter Sizes

Epilepsy and malnutrition constitute two worldwide health problems affecting behavior and brain function. The cholinergic agonist pilocarpine (300–380 mg/kg; single administration) reproduces the human type of temporal lobe epilepsy in rats. Pilocarpine-induced epilepsy in rodents has been associate...

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Bibliographic Details
Main Authors: Elian da Silva Francisco, Rubem Carlos Araújo Guedes
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Neuroscience
Subjects:
anxiety-like behavior
blood glucose
brain excitability
litter size
nutritional deficiency
pilocarpine
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2018.00897/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2018.00897/full

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