Generation of a human induced pluripotent stem cell line from an epilepsy patient carrying mutations in the PIK3R2 gene

A 48-year-old female epilepsy patient of Han Chinese genetic descent carrying heterozygous mutations in PIK3R2 donated her peripheral blood mononuclear cells (PBMCs). The PBMCs were reprogrammed by the nonintegrating vector system with human OKSM transcription factors. The generated iPSCs contained...

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Bibliographic Details
Main Authors: Bei Zhang, Yishu Wang, Jing Peng, Yong Hao, Yangtai Guan
Format: Article
Language:English
Published: Elsevier 2020-04-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506120300131