Molecular Mechanism for p202-Mediated Specific Inhibition of AIM2 Inflammasome Activation

Molecular Mechanism for p202-Mediated Specific Inhibition of AIM2 Inflammasome Activation

Mouse p202 containing two hemopoietic expression, interferon inducibility, nuclear localization (HIN) domains antagonizes AIM2 inflammasome signaling and potentially modifies lupus susceptibility. We found that only HIN1 of p202 binds double-stranded DNA (dsDNA), while HIN2 forms a homotetramer. Cry...

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Bibliographic Details
Main Authors: Qian Yin, David P. Sester, Yuan Tian, Yu-Shan Hsiao, Alvin Lu, Jasmyn A. Cridland, Vitaliya Sagulenko, Sara J. Thygesen, Divaker Choubey, Veit Hornung, Thomas Walz, Katryn J. Stacey, Hao Wu
Format: Article
Language:English
Published: Elsevier 2013-07-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713003161

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http://www.sciencedirect.com/science/article/pii/S2211124713003161

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