Dietary and genetic disruption of hepatic methionine metabolism induce acid sphingomyelinase to promote steatohepatitis

Dietary and genetic disruption of hepatic methionine metabolism induce acid sphingomyelinase to promote steatohepatitis

Alcoholic (ASH) and nonalcoholic. (NASH).steatohepatitis are advanced.stages.of.fatty.liver.disease.Methionine adenosyltransferase 1A (MAT1A) plays a key role in hepatic methionine metabolism and germline Mat1a deletion in mice promotes NASH. Acid sphingomyelinase (ASMase) triggers hepatocellular ap...

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Bibliographic Details
Main Authors: Cristina Alarcón-Vila, Naroa Insausti-Urkia, Sandra Torres, Paula Segalés-Rovira, Laura Conde de la Rosa, Susana Nuñez, Raquel Fucho, Jose C. Fernández-Checa, Carmen García-Ruiz
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Redox Biology
Subjects:
Ceramide
Methionine
Alcoholic steatohepatitis
Nonalcoholic steatohepatitis
Amitriptyline
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722003688

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http://www.sciencedirect.com/science/article/pii/S2213231722003688

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