Sex-specific genetic modifiers identified susceptibility of cold stored red blood cells to osmotic hemolysis

Sex-specific genetic modifiers identified susceptibility of cold stored red blood cells to osmotic hemolysis

Abstract Background Genetic variants have been found to influence red blood cell (RBC) susceptibility to hemolytic stress and affect transfusion outcomes and the severity of blood diseases. Males have a higher susceptibility to hemolysis than females, but little is known about the genetic mechanism...

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Bibliographic Details
Main Authors: Fang Fang, Kelsey Hazegh, Alan E. Mast, Darrell J. Triulzi, Bryan R. Spencer, Mark T. Gladwin, Michael P. Busch, Tamir Kanias, Grier P. Page
Format: Article
Language:English
Published: BMC 2022-03-01
Series:BMC Genomics
Subjects:
Red blood cell susceptibility to hemolysis
Genome-wide association study (GWAS)
Sex difference
NHLBI recipient epidemiology donor evaluation study (REDS)-III—red blood cell omics (RBC-Omics) study
Sex-interaction
Red blood cells
Online Access:https://doi.org/10.1186/s12864-022-08461-4

Internet

https://doi.org/10.1186/s12864-022-08461-4

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