19n01, a broadly neutralizing antibody against omicron BA.1, BA.2, BA.4/5, and other SARS-CoV-2 variants of concern

19n01, a broadly neutralizing antibody against omicron BA.1, BA.2, BA.4/5, and other SARS-CoV-2 variants of concern

Summary: This study reports the isolation and characterization of a human monoclonal antibody (mAb) called 19n01. This mAb was isolated by using single-cell RNAseq of B cells from donors infected with the ancestral strain. This mAb possesses a potent and broad capacity to bind and neutralize all pre...

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Bibliographic Details
Main Authors: Melissa García-Vega, Edgar A. Melgoza-González, Sofía Hernández-Valenzuela, Diana Hinojosa-Trujillo, Mónica Reséndiz-Sandoval, Mara Anais Llamas-Covarrubias, Martín Loza-López, Olivia Valenzuela, Alan Soto-Gaxiola, Miguel A. Hernández-Oñate, Verónica Mata-Haro, Irene Cassaniti, Josè Camilla Sammartino, Alessandro Ferrari, Luca Simonelli, Mattia Pedotti, Rui Sun, Fanglei Zuo, Fausto Baldanti, Luca Varani, Harold Marcotte, Qiang Pan-Hammarström, Jesús Hernández
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:iScience
Subjects:
Immunology
Virology
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223006399

Internet

http://www.sciencedirect.com/science/article/pii/S2589004223006399

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