Genomic and Molecular Characterization of Miltefosine Resistance in Leishmania infantum Strains with Either Natural or Acquired Resistance through Experimental Selection of Intracellular Amastigotes.

Genomic and Molecular Characterization of Miltefosine Resistance in Leishmania infantum Strains with Either Natural or Acquired Resistance through Experimental Selection of Intracellular Amastigotes.

During the last decade miltefosine (MIL) has been used as first-line treatment for visceral leishmaniasis in endemic areas with antimonial resistance, but a decline in clinical effectiveness is now being reported. While only two MIL-resistant Leishmania infantum strains from HIV co-infected patients...

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Bibliographic Details
Main Authors: Annelies Mondelaers, Maria P Sanchez-Cañete, Sarah Hendrickx, Eline Eberhardt, Raquel Garcia-Hernandez, Laurence Lachaud, James Cotton, Mandy Sanders, Bart Cuypers, Hideo Imamura, Jean-Claude Dujardin, Peter Delputte, Paul Cos, Guy Caljon, Francisco Gamarro, Santiago Castanys, Louis Maes
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4849676?pdf=render

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http://europepmc.org/articles/PMC4849676?pdf=render

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