Combinatorial delivery of CPI444 and vatalanib loaded on PEGylated graphene oxide as an effective nanoformulation to target glioblastoma multiforme: In vitro evaluation

Combinatorial delivery of CPI444 and vatalanib loaded on PEGylated graphene oxide as an effective nanoformulation to target glioblastoma multiforme: In vitro evaluation

Glioblastoma multiforme (GBM) is known as the primary malignant and most devastating form of tumor found in the central nervous system of the adult population. The active pharmaceutical component in current chemotherapy regimens is mostly hydrophobic and poorly water-soluble, which hampers clinical...

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Bibliographic Details
Main Authors: Vishnu S. Mishra, Sachin Patil, Puli Chandramouli Reddy, Bimlesh Lochab
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Oncology
Subjects:
glioblastoma multiforme
A2A receptor
drug delivery
graphene oxide
PEGylation
CPI444
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.953098/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.953098/full

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