Drug delivery system for the extended-release of larotrectinib based on a biocompatible Fe-based metal-organic framework: synthesis, characterization, in vitro release properties and antitumor evaluation

Drug delivery system for the extended-release of larotrectinib based on a biocompatible Fe-based metal-organic framework: synthesis, characterization, in vitro release properties and antitumor evaluation

Larotrectinib (Lar) is an orally administered tropomyosin receptor kinase (Trk) inhibitor with broad-spectrum antitumor activity that is available in clinical dosage forms as capsules and oral solutions. Currently, corresponding research is focused on developing new extended-release formulation syst...

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Bibliographic Details
Main Authors: Lu Gan, Peng Ji, Jin-xiang Zhang, Hao Chen, Yan-sheng Yao, Zhen-kun Ren
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
larotrectinib
metal-organic framework
slow release
biocompatible
antitumor
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2023.1197484/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2023.1197484/full

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