Identification and Analysis of Unstructured, Linear B-Cell Epitopes in SARS-CoV-2 Virion Proteins for Vaccine Development

Identification and Analysis of Unstructured, Linear B-Cell Epitopes in SARS-CoV-2 Virion Proteins for Vaccine Development

The efficacy of SARS-CoV-2 nucleic acid-based vaccines may be limited by proteolysis of the translated product due to anomalous protein folding. This may be the case for vaccines employing linear SARS-CoV-2 B-cell epitopes identified in previous studies since most of them participate in secondary st...

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Bibliographic Details
Main Authors: Andrés Corral-Lugo, Mireia López-Siles, Daniel López, Michael J. McConnell, Antonio J. Martin-Galiano
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Vaccines
Subjects:
coronavirus
COVID-19
epitope prediction
epitope switch
immunoinformatics
unfolded protein response
Online Access:https://www.mdpi.com/2076-393X/8/3/397

Internet

https://www.mdpi.com/2076-393X/8/3/397

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