Determining homologous recombination deficiency scores with whole exome sequencing and their association with responses to neoadjuvant chemotherapy in breast cancer

Determining homologous recombination deficiency scores with whole exome sequencing and their association with responses to neoadjuvant chemotherapy in breast cancer

Recent studies demonstrated that homologous repair deficiency (HRD) score is a useful marker for response to poly (ADP-ribose) polymerase inhibitors or platinum-based chemotherapy. We determined HRD scores and elucidated the clinicopathologic characteristics of HRD-high tumors and their response to...

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Bibliographic Details
Main Authors: Seung Jin Kim, Yoshiaki Sota, Yasuto Naoi, Keiichiro Honma, Naofumi Kagara, Tomohiro Miyake, Masafumi Shimoda, Tomonori Tanei, Shigeto Seno, Hideo Matsuda, Shinzaburo Noguchi, Kenzo Shimazu
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:Translational Oncology
Subjects:
Breast cancer
HRD
Whole exome sequence
Neoadjuvant chemotherapy
Prediction
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523320304782

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http://www.sciencedirect.com/science/article/pii/S1936523320304782

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