Nucleosome positions establish an extended mutation signature in melanoma.

Nucleosome positions establish an extended mutation signature in melanoma.

Ultraviolet (UV) light-induced mutations are unevenly distributed across skin cancer genomes, but the molecular mechanisms responsible for this heterogeneity are not fully understood. Here, we assessed how nucleosome structure impacts the positions of UV-induced mutations in human melanomas. Analysi...

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Bibliographic Details
Main Authors: Alexander J Brown, Peng Mao, Michael J Smerdon, John J Wyrick, Steven A Roberts
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-11-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1007823

Internet

https://doi.org/10.1371/journal.pgen.1007823

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