A SPOPL/Cullin-3 ubiquitin ligase complex regulates endocytic trafficking by targeting EPS15 at endosomes

A SPOPL/Cullin-3 ubiquitin ligase complex regulates endocytic trafficking by targeting EPS15 at endosomes

Cullin-3 (CUL3)-based ubiquitin ligases regulate endosome maturation and trafficking of endocytic cargo to lysosomes in mammalian cells. Here, we report that these functions depend on SPOPL, a substrate-specific CUL3 adaptor. We find that SPOPL associates with endosomes and is required for both the...

Full description

Bibliographic Details
Main Authors: Michaela Gschweitl, Anna Ulbricht, Christopher A Barnes, Radoslav I Enchev, Ingrid Stoffel-Studer, Nathalie Meyer-Schaller, Jatta Huotari, Yohei Yamauchi, Urs F Greber, Ari Helenius, Matthias Peter
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-03-01
Series:eLife
Subjects:
endocytosis
influenza A virus
EGFR
CUL3
SPOPL
EPS15
Online Access:https://elifesciences.org/articles/13841

Internet

https://elifesciences.org/articles/13841

Similar Items