Penetration into Cancer Cells via Clathrin-Dependent Mechanism Allows L-Asparaginase from <i>Rhodospirillum rubrum</i> to Inhibit Telomerase

Penetration into Cancer Cells via Clathrin-Dependent Mechanism Allows L-Asparaginase from <i>Rhodospirillum rubrum</i> to Inhibit Telomerase

The anticancer effect of L-asparaginases (L-ASNases) is attributable to their ability to hydrolyze L-asparagine in the bloodstream and cancer cell microenvironment. <i>Rhodospirillum rubrum</i> (RrA) has dual mechanism of action and plays a role in the suppression of telomerase activity....

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Bibliographic Details
Main Authors: Anna A. Plyasova, Marina V. Pokrovskaya, Olga M. Lisitsyna, Vadim S. Pokrovsky, Svetlana S. Alexandrova, Abdullah Hilal, Nikolay N. Sokolov, Dmitry D. Zhdanov
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Pharmaceuticals
Subjects:
<i>Rhodospirillum rubrum</i>
L-asparaginase
telomerase
endocytosis
clathrin
dynamin
Online Access:https://www.mdpi.com/1424-8247/13/10/286

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https://www.mdpi.com/1424-8247/13/10/286

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